Ten Unconventional Knowledge About Medicinally Important Herbal Flowers In Sri Lanka How To Benefit Covid-19 That You Can't Learn From Books.
Two viral proteases of SARS-CoV, a chymotrypsin-like protease (3 CL(pro)) and a papain-like protease (PL(pro)) are attractive targets for the development of anti-SARS drugs.
Herbal medicine as vaccine adjuvants
In this case, the vegetal source is of extreme importance as propolis from Europe and temperate Asia, usually made by bees from resins collected from Poplar trees, has predominantly flavonoid compounds, while green propolis (from Baccharis dracunculifolia), propolis exclusively found in Brazil, has various kinds of flavonoids and prenylated phenylpropanoids, such as repelling C, baccharin, and drupanin.
In recent years,
there have been a number of reports on the herbal extracts/isolated compounds
as adjuvant agents for enhancing the
efficiency of weakly
immunogenic vaccines. Up to now, most of these combinations are applied în
veterinary medicine, but human clinical
trials are ongoing
Quercetin (IC) = 73 μM), epigallocatechin gallate (IC(50) = 73 μM) and
gallocatechin gallate (GCG) (IC) = 47 μM) displayed good inhibition toward
3CLPro. GCG showed a competitive inhibition pattern with a K value of
25 ± 1.7 μM. In molecular docking experiments, GCG displayed binding
energy of −14 kcal mol(−1) to the active site of 3CL(pro) and the galloyl
moiety at 3-OH position was required for 3CL(pro) inhibition activity.
Apigenin moiety at position C-3ʹ of flavones appeared to be more effective
as suggested by Ryu et al., 2010.
The research team found 3CL(pro)
inhibitory effect of amentoflavone
(IC) = 8.3 μM), apigenin (IC) = 280.8
μM), luteolin (IC) = 20.2 μM),
and quercetin (IC) = 23.8 μM but also
of the ethanol extract of Torreya
Nucifera leaves traditionally used as a
medicinal plant in Asia
(62% at 100 μg/mL). Previous studies
revealed that also
quercetin-3-beta-galactoside is a potent
inhibitor of the protease and further
structure-activity relationships of the
new compounds were proposed:
removal of the 7-hydroxy group of the
quercetin moiety decreases the
bioactivity of the derivatives;
acetylation of the sugar moiety abolishes
inhibitor action; introduction of
a large sugar substituent on 7-hydroxy
of quercetin can be tolerated;
replacement of the galactose moiety with
other sugars does not affect inhibitor potency
Background. The plant kingdom is rich with a numerous number of plants with various medical properties which can be used to treat various medical issues. Sri Lanka is a country full of biodiversity which is gifted with many plant resources. It has a rich history of traditional medicine systems consisting of Ayurveda, Unani, and Deshiya Chikitsa, where these plant resources are used as remedies for the diseases. In the traditional medicine system, various plant parts such as leaves, roots, fruits, flowers, and bark are used to treat disease conditions. Although less attention is paid to the medicinal importance of the flowers, some of them have been used to treat many diseases from the ancient time. Some properties of the flowers may differ from the properties of the other plant parts. For example, Sesbania grandiflora (Katuru murunga) flowers have shown anticancer properties against various cell models whereas some flowers have shown antispermatogenic properties.
Flowers of Woodfordia floribunda
(Militta) are added as fermenting agents in the preparation of Arishtas in
Ayurveda. Also the most popular Clove oil is obtained from the flower buds of
Syzygium aromaticum (Karabu-nati) which is used to treat toothaches since it
has antibiotic and antiseptic properties. This article gives an overview of
herbal flowers used in the traditional medicine system of Sri Lanka and their
pharmacological importance. Method. A comprehensive literature survey was done
on the medicinally important flowers in Sri Lanka. Data was collected from
Libraries of Ayurveda in Sri Lanka and fro
Plants have been used by human beings
to cure diseases of ancient times. Therefore herbal drugs play a major role in
traditional medicine. According to the World Health Organization (WHO), herbal
drugs are the best source to obtain a variety of drugs. In developing
countries, about 80% of the population depends on traditional medicine.
Traditional medicine which is mainly based on plant sources consists
of significant amounts of bioactive compounds. These compounds provide valuable
health effects. Since modern medicine claimed to possess irreversible adverse
events, herbal plants play a major role in delivering therapeutic effects with
less adverse events to human beings
Sri Lanka is a country full of
biodiversity which is gifted with many plant resources. It has been reported
that there are 3771 flowering plant species grown in Sri Lanka. Out of them
about 927 (24%) are endemic to the country. Also, 1430 species are considered
to have medicinal value. Out of these medicinal plants, 174 (12%) are endemic
to Sri Lanka. Also, it is reported that around 250 species are commonly used in
traditional medicine. Since there are a huge number of medicinal plants in Sri
Lanka, it has a rich history of traditional medicine systems.
The main traditional medicine systems that prevail in Sri Lanka are
Ayurveda, Siddha, Unani, and Deshiya Chikitsa. In Ayurveda, herbal preparations
are used mostly to cure diseases while in Siddha mineral preparations are used
mostly. Deshiya Chikitsa also uses herbal preparations. The Unani differs from
these concepts. Ayurveda system of Sri Lanka nearly uses 2000 herbs . These
systems fulfill 60-70% of the rural populations’ primary health care needs. The
knowledge regarding the use of these herbal plants has been passed from
generation to generation in the traditional medicine systems. So there are
numerous plants with valuable health benefits used in these traditional
formulations where the knowledge regarding the therapeutic use is depleting day
by day
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